Analysis of naturally acquired immune responses against the <i>Plasmodium falciparum</i>malaria vaccine candidate PF3D7_1136200

Abstract Humoral immunity is critical for protection against Plasmodium falciparum malaria. In endemic areas, individuals acquire protective malaria through repeated exposure to P. parasites. Understanding these naturally acquired immune responses would be highly informative the development of improved vaccination strategies Antibody uncharacterized protein PF3D7_1136200 correlate with from malaria, however, antibody over time and their role in protecting remain unknown. Here, we compared PF3D7_1136200-specific B cell that other antigens Ugandan different status: adults (n=24) children high (n=10) or low (n=8) susceptibility all groups, serum reactivity MSP1, MSP3, AMA1, VFT, Pf41, Pf113 was dominated by IgG. contrast, IgG much lower, while IgM at a similar higher level antigens. line among adults, exclusively observed +memory cells (MBCs) PF3D7_1136200, +MBCs were more abundant than These results indicate has antigenic profile, favorable vaccine candidates, suggest potential shielding antigen host system. Together genetic conservation characteristics highlight Pf3D7_1136200 as novel candidate Supported grants NIH (R01 AI153425, P30 CA054174-20)